Review article: Gunjan Subedi, Kathmandu University
on Enhancing the solubility of poorly water soluble drugs.
Abstract :
Each
drug molecule have own inherent material properties (physical\chemical) such as
solubility which varies from one to another. As more than one third of drug
molecule of US Pharmacopoeia are listed under class of poorly soluble or
insoluble, conversion of such drug candidate ( poor soluble or insoluble)
always makes challenge to formulate and develop dosage form with better
bioavailability where solubility act as key determinant for absorption. A
researcher's ultimate objective is to maximize the solubility characteristics
of such molecule. In order to achieve such objectives we have to modify their
inherent physical as well chemical properties (without altering therapeutic
value) by applying any of the above discussed physical/ chemical/other
techniques based on their material properties. The approaches described here
are of great help in enhancing the solubility of poorly soluble drug molecules
shows great promise for development of dosage forms using such APIs.
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